Bizcase:Alzheimer PSEN2

Actor: Sales guy
Country: France
Scheduled visit: Sorbonne University
Opportunity: New HS Preselin2 Elisa Kit
BizCase: Alzheimer disease and genes
Opportunity: Enlarge the base of customers, provide the portfoglio contains Ab,protein or Kit elisa for

Understand alzheimer (brief)
Alzheimer's disease is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and personality changes. It is the most common cause of dementia among older adults. Understanding the genetic factors contributing to Alzheimer's is crucial for early diagnosis, risk assessment, and developing targeted therapies. Genetic research has identified several genes that play a significant role in the development and progression of Alzheimer's disease.
Genetic Basis of Alzheimer's Disease

Genetics is the study of heredity and the variation of inherited characteristics. In the context of Alzheimer's, genetics helps in identifying specific genes that increase the risk of developing the disease. Alzheimer's can be classified into two main types based on genetic involvement: familial Alzheimer's disease (FAD) and sporadic Alzheimer's disease. FAD is typically associated with mutations in specific genes, whereas sporadic Alzheimer's involves a more complex interplay of genetic and environmental factors.
Key Genes Associated with Alzheimer's

1. APP (Amyloid Precursor Protein)

The APP gene is located on chromosome 21. Mutations in this gene can lead to the overproduction of amyloid-beta peptides, which aggregate to form plaques, a hallmark of Alzheimer's pathology. Mutations lead to the abnormal cleavage of APP, resulting in the formation of amyloid-beta plaques.

2. PSEN1 (Presenilin 1)
PSEN1 is located on chromosome 14. Mutations in this gene are the most common cause of early-onset familial Alzheimer's disease. PSEN1 mutations affect the cleavage of APP, leading to an increase in amyloid-beta production. involved in the gamma-secretase complex that processes APP. Mutations in these genes result in the overproduction of pathogenic amyloid-beta peptides.

3. PSEN2 (Presenilin 2)
The PSEN2 gene, located on chromosome 1, is less commonly associated with Alzheimer's. Like PSEN1, PSEN2 mutations also affect APP processing and amyloid-beta production. involved in the gamma-secretase complex that processes APP. Mutations in these genes result in the overproduction of pathogenic amyloid-beta peptides.

4. APOE (Apolipoprotein E)
The APOE gene on chromosome 19 is involved in lipid metabolism. The APOE ε4 allele is a well-established genetic risk factor for late-onset Alzheimer's disease. Individuals with one or two copies of the ε4 allele have an increased risk of developing Alzheimer's compared to those with the more common ε3 allele.
The ε4 variant of APOE is less effective in clearing amyloid-beta from the brain, leading to its accumulation and plaque formation.
Reactome link to the alzheimer
Genetex website link
Abcam Website Link
MyBiosource WebSiteLink

1) Open Biorecommender, Concept, Search for Alzhe.... and:
1a) select Alzheimer's disease
1b) set a recent date (May 2023)
1c) Set country filter asd France
1d) Look for institute, third colum, and select Sorbonne with the icon link on the right (open a new session)

2) The new opened session is now only on Sorbonne University, and the filters are already set as the previous selection

If you have a special product for PSEN2, a new elisa with high sensivity for example, you can filter in the works text PSEN2, and get your report to contact people

Now , you can in the product session list who is offering the elisa, here the MyBiosource list: